The database of Genotypes and Phenotypes (dbGaP) was developed to archive and distribute the results of studies that have investigated the interaction of genotype and phenotype. Such studies include genome-wide association studies, medical sequencing, molecular diagnostic assays, as well as association between genotype and non-clinical traits. The advent of high-throughput, cost-effective methods for genotyping and sequencing has provided powerful tools that allow for the generation of the massive amount of genotypic data required to make these analyses possible.
dbGaP provides two levels of access - open and controlled - in order to allow broad release of non-sensitive data, while providing oversight and investigator accountability for sensitive data sets involving personal health information. Summaries of studies and the contents of measured variables as well as original study document text are generally available to the public, while access to individual-level data including phenotypic data tables and genotypes require varying levels of authorization.
Please note that this is a general description of what is available to open- access users. Data available to open-access users may vary between studies and may also differ from what is described here without notice. You can find more details regarding data access policies for specific studies on the individual study report pages.
Controlled-access data can only be obtained if a user has been authorized by the appropriate Data Access Committee (DAC). Information on requesting controlled data access, is available below. Data available to authorized investigators may include the following:
Since data access policies are determined on a per-study basis, data available to users with controlled access authorization may vary between studies and may also change from what is described here without notice. You can find more details regarding data access policies for a specific study on the study report page along with a link to the appropriate authorizing body.
Access to controlled data in dbGaP will be granted by an NIH Data Access Committee or DAC. Users wishing access to controlled data must submit a Data Use Certification, or DUC, to the appropriate NIH DAC for approval. DAC approval for controlled data access will be dependent upon completion of the DUC, and confirmation that the proposed research use is consistent with patient consent forms and any constraints identified by the institutions that submitted the dataset(s) to dbGaP. Links to a study's DAC will be found on the study report page.
Submitters of controlled-access data housed in dbGaP may retain the exclusive right to publish an analysis of their submitted data for a specified period of time. Users of controlled-access data should consult the DUC or the study report page to determine the specific publishing exclusivity period for that study.
Access to individual-level data housed in dbGaP is under the jurisdiction of the sponsoring institute. Therefore, any questions regarding access to controlled data should be directed to the DAC for the study in question, and not to NCBI.
September 13, 2010